This book constitutes the refereed proceedings of the 27th International Conference on Applications of Natural Language to Information Systems, NLDB 2022, held in Valencia, Spain in June 2022. The 28 full papers and 20 short papers were carefully reviewed and selected from 106 submissions. The papers are organized in the following topical sections: Sentiment Analysis and Social Media; Text Classification; Applications; Argumentation; Information Extraction and Linking; User Profiling; Semantics; Language Resources and Evaluation.